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General Precautions about Xanax and Using Xanax with Other Drugs


should not be prescribed to anyone who is younger than 18 years old.

Since Xanax suppresses the central nervous system, it should not be taken by someone who needs to be fully alert to perform activities, such as driving a vehicle or operating machinery. Alcoholic beverages should not be taken with Xanax.

Mixing grapefruit juice, or grapefruit, with Xanax can result in negative side effects, so the two should not be mixed together.

Patients who are sensitive to any benzodiazepine drug should not take Xanax, since it belongs to the same class of medications. Medical help should be immediately sought if indications of an allergic reaction occur, such as swelling, itching, a rash, extreme dizziness or trouble breathing. This type of reaction most often occurs with swelling or an itchy feeling in the tongue, throat or facial region.
Pregnant women should not take Xanax, since any benzodiazepine can be harmful to unborn babies. Benzodiazepines, which is a drug classification to which Xanax belongs, is known to cause birth defects when taken during the first trimester of pregnancy. Also, children born to patients taking benzodiazepines have a risk of withdrawal symptoms, such as respiratory issues and limp muscle mass. Xanax is known to pass through breast milk, so women should not breast feed babies while taking this medication.

Anyone who is severely depressed or who has plans of suicide is cautioned from taking Xanax, since suicide can take place after taking any psychotropic drug, such as Xanax. Another potential with anyone who suffers depression and then takes Xanax is episodes of mania or hypomania.

The elderly can have a higher sensitivity to the side effects of Xanax, particularly getting sleepy and the loss of coordination side effects. Consequently, Xanax might be required to be administered in smaller doses to older patients, as compared to younger patients. Those who suffer from open angle glaucoma can take Xanax, but anyone with acute narrow angle glaucoma should not be administered Xanax.

Studies show that Asians retain Xanax at a 15 to 25 percent higher rate than other races of people. Those who consume tobacco see a 50 percent reduction in the effectiveness of Xanax, as compared to patients who do not smoke.

Before going through any kind of surgery or undergoing dental work, the doctor or dentist should be told that you are taking Xanax and any other medications that are being used, including nonprescription drugs, prescription drugs and even herbal products.

It is important that when taking Xanax tablets with other medications that they aren’t mixed with drugs that result in severe side effects when combined with benzodiazepines. If the other medication is a psychotropic, anticonvulsive, antihistamine drug or an alcoholic drink, which depresses the central nervous system, an attribute of Xanax, the combination of the two drugs might be too much for the patient to bear.

Caution is recommended in combining Xanax with drugs that affect an enzyme in the brain called CYP3A. Drugs that involve CYP3A enzyme include fluoxetine, also known as Sarafem, PROzac Pulvules, Selfemra, Rapiflux, PROzac Weekley and PROzac; and propoxyphene, with brand names of PC-Cap, Darvon Compound-65, Darvon Compound 32, Propoxyphene Compound 65, Trycet, Darvocet A500, Darvocet-N 50, Darvocet-N 100, PP-Cap, Darvon-N and Darvon.

Some medications effectively remove Xanax from your body and should not be taken together with the drug. Azole antifungal medications should be avoided when taking Xanax. They include ketoconazole, also called Kuric, Xolegel, Nizoral A-D, Nizoral Topical, Nizoral, Xolegel+Plus, Xolegel CorePak and Xolegel Duo; itraconazole, which sells as Onmel, Sporanox PulsePak, and Sporanox; and cimetidine, also called Equaline Acid Reducer, Tagamet HB and Tagamet.

Some anti-depressant drugs should be avoided when taking Xanax, such as nefazodone, that is also called Serzone; and fluvoxamine, which goes by the name of Luvox CR and Luvox. Also, some antibiotics, such as erythromycin, also called A/T/S, Akne-Mycin, Romycin, Erygel, Roymicin, Eyemycin, Ilotycin, Erythrocin, Ery-Tab, EryPed and E-Mycin; rifabutin, which goes by the name of Mycobutin; should not be used while taking Xanax, along with St. John’s wort.

Kava, a product of the Western Pacific region of the world, which is also known as kava-kava, ‘awa, ava, yaqona and sakau, is a drink that comes from a plant root which is a sedative and has painkilling properties. It interacts with Xanax and, therefore, should not be ingested while taking the drug.
Sodium oxybate, also known as gamma hydroxybutyrate (GHB), which is known by the brand name, Xyrem, is narcotic sedative used to treat the narcolepsy sleep disorder. GHB interacts with Xanax, so the two drugs should never be taken together.

Drugs that can make you sleepy shouldn’t be taken together with Xanax. One medication is a specific antihistamine known as diphenhydramine, which can also be called Sleep, ZzzQuil, Silphen, Dicopanol, Hydramine, Wal-Dryl, Diphenhist, Banophen, Sominex, Benadryl Allergy and Benadryl. Other over-the-counter medications that contain diphenhydramine include Banophen Anti Itch, Benadryl Extra Strength Spray, SM Anti-Itch, Diphenhist Topical, Di-Delamine, Benadryl Children’s Allergy And Sinus, Benadryl Allergy Sinus, Tekral, Benaphen Plus, Delsym Children’s Night Time Cough & Cold, PediaCare Children’s Allergy & Cold, Alahist LQ, Dytan-D, Doans PM, First BXN Mouthwash, Advil PM, Ibuprofen PM, Motrin PM, FIRST Mary’s Mouthwash, FIRST Duke’s Mouthwash, HC-Derma-Pax, Rindal HPD, Endal HD, Hydro-DP, Tussinate, D-Tann DM, Duratuss AC 12, Dytan-DM, Endal CD, Airacof, Dytan-CD, Uni-Tann CS, D-Tann CT, Dytan-CS, D-Tann AT, Dytan-AT, Invarest, Ivarest, Calamine with Antihistamine, Ala-Hist D, Ala-Hist, Alka-Seltzer PM, Bayer PM, FIRST Mouthwash BLM, Contact Day and Night Allergy, Benadryl Severe Allergy & Sinus Headache, Benadryl Cold, Sudafed Sinus Nighttime Plus Pain, Cold & Flu, Robutussin Night Time Cough, CounterAct Night, Theraflu Warming Relief Nighttime Severe Cold & Cough, Benadryl Allergy Plus Cold, Percogesic Extra Strength, Pain Reliever PM, Pain Relief PM Extra Strength, Tylenol PM, Contact Day and Night Cold and Flu, Respa C&C IR, Respa C&C, Diabetic Tussin Night Time Formula, Banophen M-S, Dermarest Plus, Benadryl Extra Strength Itch Stopping Gel and Dermarest.

One more type of drug, which doesn’t mix with Xanax and induces drowsiness is the narcotic pain reliever, codeine, which has brand names the like Pro-Clear AC, Triafed & Codeine, Allerfrin with Codeine, Polyhist NC, Triacin C, Neo AC, Nucodine, Cycofed, KG-Fed, Nucofed, Promethazine HCL and Codeine Phosphate, Codeine Phosphate-Promethazine HCI, Phenergan with Codeine, Promethazine with Codeine, Pro-Red AC, Dicomal-PH, Zotex-C, Codimal PH, Penergan VC with Codeine, Promethazine VC with Codeine, Notuss-PE, Ala-Hist AC, Tussirex Sugar Free, Tussirex, Mytussin CAD, Guiatuss DAC, Deproist with Codeine, Cheratussin DAC, Endal Expectorant, Enditussin Expectorant, Efasin Expectorant SF, Alphen Expectorant, Maxiphen CDX, Maxiphen CD, Giltuss Ped-C, Tridal, Guiatuss AC, Iophen-C NR, Robitussin-AC, Cheratussin AC, Endal CD, Airacof, Vanacof CD, M-End Max D, Codehist DH, Decohistine DH, Phenylhistine DH, Dihistine DH, Demi-Cof, Pedituss, Pediacof, T-koff, CapCof, Lexuss 210 Liquid, Notuss-AC, Codeprex, Cotab AX, Statuss Green, Notuss-NXD, Nasotuss, Notuss-NX, Mar-cof BP, M-End WC, Trihist-CS, Poly-Histine CS, Myphetane DC, Dietane DC, BroveX PB XC, BroveX PB C, M-End PE, Poly-Tussin AC, BroveX CBX, BroveX CB, EndaCof-AC, Nalex AC, Empirin with Codeine, Soma Compound with Codeine, Fiortal with Codeine, Ascomp with Codeine, Fiorinal with Codeine III, Fiorinal with Codeine, Rolatuss, Maxiflu CDX, Maxiflu CD, Phenflu CDX, Phenflu CD, Cocet, Tylenol with Codeine #4, Tylenol with Codeine, Tylenol with Codeine #3, Colrex Compound, Colrex, Cotabflu, Phrenilin with Caffeine and Codeine, Floricet with Codeine and Fioricet with Codeine.

Other medications, which can cause drowsiness and shouldn’t be taken with Xanax include drugs used for sleep or anxiety, such as diazepam, also known as Diazepam Intensol, Diastate AcuDial, Diastat and Valium; muscle relaxing drugs, and psychiatric medications, such as chlorpromazine, also called Ormazine, Thorazine; risperidone, known as Olanzapine, Aripiprazole, Quetiapine, Risperdal M-Tab, Risperdal Consta and Risperdal; amitriptyline, that goes by the brand names of Etrafon Forte, Etrafon, Triavil, Limbitrol DS, Limbitrol, Vanatrip, Endep and Elavil; and trazadone, known as Citalopram, Flouxetine, Sertraline, Dividose, Desyrel, Oleptro and Desyrel.

Xanax shouldn’t be taken if you are already taking birth control pills. Inform your doctor before Xanax is prescribed to you if you’re already taking the antibiotic called cyclosporine, which goes by the brand names of Sandimmune, Neoral, Gengraf, Restasis; dexamethasone, that is known as DexPak, Sourex, Dexasone, Cortastat, Baycadron, Maxidex, Ozurdex, Decadron, Hexadrol, Injectable, Decadron Phosphate, Insensol, Dexamethasone, Dexasol, Decadron Ocumeter, Ciprodex, Decadron with Xylocaine, Neo-Dex, AK-Neo-Dex, Neo-Decadron Ocumeter, Neo-Decadron, Dexasporin, Dexacidin, Neo-Poly-Dex, Maxitrol, Tobradex ST and TobraDex; ergotamine, also known as Migergot, Ergomar, Cafergot, Wigraine, Cafatine, Bel-Phen-Ergot, Bellamor, Bellamine, Bellergal-S, Ergocomp-PB, Micomp-PB, Cafatine PB and Belcomp PB; imatinib, which is also known as Gleevec; isoniazid, which is used to treat tuberculosis and is also called Nydrazid; the antibiotic known as clarithromycin, that also goes by the names of Omeclamox-Pak, Prevpac, Biaxin XL and Biaxin; rifampin, an antibiotic with brand names of IsonRif, Rifamate, Rifater, Rifadin IV, Rimactane and Rifadin; rifapentine, another antibiotic which is also called Priftin; miconazole, an antifungal medicine that can also be named Rash Relief Antifungal, Daktozin, Vusion, Lotrimin AF Athlete’s Foot Spray, Monistat 7-Day Combination, Monistat 3-Day Combination Pack, Monistat and Oravig; voriconazole, another antifungal medicine with the brand name of Vfend; desipramine, an antidepressant also known as Norpramin; imipramine, another antidepressant with brand names of Tofranil-PM, Tofranil and Janimine; butabarbital, which is a barbiturate also called Phenaz Plus, Urelief Plus, PhenazoForte Plus, Busodium, Butisol Sodium and Butisol; secobarbital, another barbiturate with other names of Tuinal, Seconal Sodium and Seconal; pentobarbital, a barbiturate which also is called Nembutal Sodium and Nembutal; phenobarbital, a barbiturate also named Levsin with Phenobarbital, Tedrigen, Theodrine, Qudrinal, Lufyllin-EPG, Elixiral, Donnatal Extentabs, Antispasmodic, Donnatal, Mudrane, Mudrane GG, Luminal and Solfoton.

Your doctor should be informed before you take Xanax if you take blood pressure or heart medication, such as amiodarone, that can be called Cordarone IV, Nexterone, Pacerone or Cordarone; diltiazem, with the brand names of Ticzem, Dilt-CD, Cartia XT, Cardizem CD, Cardizem, Cartia and Tiazac; nicardipine, also called Cardene SR, Cardene IV and Cardene; nifedipine, with brand names of Adalate XL Plus, Procardia XL, Adalate, Procardia and Nifedical; and quinidine, that goes by Nuedexta, Quinora, Quinidex Estentabs, Cardioquin, Quinaglute Dura-Tabs and Quin-G.

If you are taking drugs to treat HIV/AIDS, your doctor should be notified before taking Xanax. Such medications include atazanavir, which is also named Reyataz; delavirdine, which is also called Rescriptor; and indinavir, with a brand name of Crixivan; etravirine, known as Intelence; nevirapine, with other names of Viramune XR and Viramune; nelfinavir, also called AccessPak for HIV PEP Expanded with Viracept and Viracept; saquinavir, known as Foravase and Invirase; and ritonavir, that is also called AccessPak for HIV PEP Expanded with Kaletra, Kaletra, Norvir Soft Gelatin and Norvir.


You need to tell your doctor if you take drugs to treat seizures before being administered Xanax. Such medications include carbamazepine, which goes by the names of Equetro, Epitol, Tegretol XR, Carbatrol and Tegretol; phenytoin, which doubles as Phenytoin Sodium and Dilantin; felbamate, also called Felbatol; oxcarbazepine, which goes by the names of Oxtellar XR and Trileptal; and primidone, which is also called Mysoline.